Inhibition of herpes simplex virus type 1 by small interfering RNA
نویسندگان
چکیده
منابع مشابه
Inhibition of herpes simplex virus type 1 infection by Sambucus ebulus extract in vitro
Background: The emergence of drug-resistant strains of herpes simplex virus type 1 (HSV-1) has been increasingly reported. Therefore, attempts to discover new antiviral agents in particular from natural compounds are required. In this study, we evaluated the possible inhibitory effects of hydroalcoholic extract of Sambucus ebulus (S. ebulus) against HSV-1. Methods: S. ebulus extract was pro...
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RNA interference (RNAi) is an antiviral mechanism that is activated when double-stranded RNA is cleaved into fragments, called short interfering RNA (siRNA), that prime an inducible gene silencing enzyme complex. We applied RNAi against a herpes simplex virus type 1 (HSV-1) gene, glycoprotein E, which mediates cell-to-cell spread and immune evasion. In an in vitro model of infection, human kera...
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ژورنال
عنوان ژورنال: Clinical and Experimental Dermatology
سال: 2007
ISSN: 0307-6938,1365-2230
DOI: 10.1111/j.1365-2230.2007.02543.x